141??????? and 142??????? is uniquely generated RunOnce program for Adobe Speed Launcher

This behavior is new with the latest update to Adobe Reader XI.

They have known about it since December 2014 and issued a patch but have yet to fix their fully installed version of the product.
When Adobe Speed Launcher runs, it automatically creates a new RunOnce key with a unique name like 1418530337 each time in order to regnerate itself after the next reboot.

*** It has been confirmed that Solution 2 at the link below does resolve the problem.
Adobe Patch

The purpose of Adobe Speed Launcher is to preload much of the binaries and files needed by Adobe Reader at system start-up so that if you use Adobe Reader it will open more quickly for you.


If you would like to read more, please read our article about tracking down the mysterious RunOnce key that resulted in our identifying Adobe Speed Launcher.

Safe

But, given how it works we must still mark Adobe Reader and thus Adobe Speed Launcher as Remove